“A new peer-reviewed study published in the journal Toxicological Research & Application shows acute exposure of a 3D human bronchial tissue model to e-cigarette aerosol has minimal impact on gene expression compared to smoke from combustible cigarettes. “Within this model, exposure to combustible cigarette smoke triggered significant changes in gene expression, indicating – amongst other effects – changes in oxidative stress and inflammation markers,” confirmed Matt Stevenson, Pre-Clinical Toxicology Manager at Imperial Brands. “Conversely, the vape aerosol generated only a minimal response, similar to that observed in the air control.” The results from this study show, that under the conditions of test, acute exposure to vape aerosol had less impact on gene expression in human lung cells in vitro than the equivalent dose of cigarette smoke. “We encourage regulators and policy makers to consider the weight of evidence that shows the clear scientific differences between combustible cigarettes, which burn tobacco, and potentially harm-reduced NGPs [ππ¦πΉπ΅ ππ¦π―π¦π³π’π΅πͺπ°π― ππ³π°π₯πΆπ€π΅π΄ ππͺπ¬π¦ π·π’π±π¦π΄] that do not,” he concluded.”
ARTICLE LINK:
Vape aerosol and gene expression in human lung tissue compared to cigarette smoke
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