“Imperial Brands scientists have utilised Toxys’ ToxTracker suite of stem-cell based in-vitro assays, which provide mechanistic insight into the potential DNA damaging properties of chemicals, comparing vape e-liquid samples and their aerosols to combustible cigarette smoke. “Overall, the data from our latest study adds to the weight of scientific evidence demonstrating vape products offer significant harm reduction potential compared to combustible cigarettes,” says Lukasz Czekala, Senior Pre-Clinical Toxicologist at Imperial Brands and lead author of the paper. Results showed that:
-
Vape aerosols trapped in a buffer solution did not induce responses in any of the six cell lines.
-
Undiluted flavoured e-liquids (tested up to 1%) did induce both oxidative stress reporters, but this was considered an effect of osmolarity (a measure of solution concentration) caused by PG/VG in an in-vitro testing environment.
-
Nicotine content did not affect responses: tobacco flavour e-liquid at either 1.6% freebase nicotine, 1.6% nicotine salt or nicotine-free produced the same results.
-
In addition, nicotine (tested alone) only produced an oxidative stress response at levels that would be a concentration of more than 40,000 times higher than found in the blood from typical smoking.”
ARTICLE LINK: Vaping vs. smoking: Impact on cells compared
Store
